PETER VANGHELUWE'S LIST OF PUBLICATIONS

van Veen, S.*, Martin, S.* Van den Haute, C., Benoy, V., Lyons, J., Vanhoutte, R., Kahler, J.P., Decuypere, J.-P., Gelders, G., Lambie, E., Zielich, J., Swinnen, J.V., Annaert, W., Agostinis, P., Ghesquière, B., Verhelst, S., Baekelandt, V., Eggermont, J., Vangheluwe, P. (*equal contribution) ATP13A2 deficiency disrupts lysosomal polyamine export. NATURE, In press  doi: 10.1038/s41586-020-1968-7

Chen, J., Sitsel, A., Benoy, V., Sepúlveda, M.R., Vangheluwe, P. (2019). Primary Active Ca2+ Transport Systems in Health and Disease. Cold Spring Harb Perspect Biol. In press doi: 10.1101/cshperspect.a035113

Herrmann, A-K., Wuellner, V., Moos, S., Graf, J., Chen, J., Kieseier, B., Kurschus, F.C., Albrecht, P., Vangheluwe, P., Methner, A. (2019). Dimethyl fumarate alters intracellular Ca2+ handling in immune cells by redox-mediated pleiotropic effects. FREE RADICAL BIOLOGY AND MEDICINE, 141, 338-347. doi: 10.1016/j.freeradbiomed.2019.07.005

Chen, J., Smaardijk, S., Mattelaer, C-A., Pamula, F., Vandecaetsbeek, I., Vanoevelen, J., Wuytack, F., Lescrinier, E., Eggermont, J., Vangheluwe, P. (2019). An N-terminal Ca2+-binding motif regulates the secretory pathway Ca2+/Mn2+-transport ATPase SPCA1. JOURNAL OF BIOLOGICAL CHEMISTRY, 294 (19), 7878-7891. doi: 10.1074/jbc.RA118.006250 Open Access

Gorski, P.A., Jang, S.P., Jeong, D., Lee, A., Lee, P., Oh, J.G., Chepurko, V., Yang, D.K., Kwak, T.H., Eom, S.H., Park, Z-Y., Yoo, Y.J., Kim, D.H., Kook, H., Sunagawa, Y., Morimoto, T., Hasegawa, K., Sadoshima, J., Vangheluwe, P., Hajjar, R.J., Park, W.J., Kho, C. (2019). Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure. Circ Res, 124 (9), e63-e80. doi: 10.1161/CIRCRESAHA.118.313865

Wauters, F., Cornelissen, T., Imberechts, D., Martin, S., Koentjoro, B., Sue, C., Vangheluwe, P., Vandenberghe, W. (2019). LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10. AUTOPHAGY. doi: 10.1080/15548627.2019.1603548

Sitsel, A., De Raeymaecker, J., Drachmann, N.D., Derua, R., Smaardijk, S., Andersen, J.L., Vandecaetsbeek, I., Chen, J., De Maeyer, M., Waelkens, E., Olesen, C., Vangheluwe, P., Nissen, P. with Vangheluwe, P. (joint last author), Nissen, P. (joint last author) (2019). Structures of the heart specific SERCA2a Ca2+-ATPase. EMBO JOURNAL. doi: 10.15252/embj.2018100020 Open Access

Bittremieux, M., La Rovere, R.M., Schuermans, M., Luyten, T., Mikoshiba, K., Vangheluwe, P., Parys, J.B., Bultynck, G. (2018). Extracellular and ER-stored Ca2+ contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells. CELL DEATH DISCOVERY, 4, Art.No. ARTN 101. doi: 10.1038/s41420-018-0118-6 Open Access

Pessina, F., Gamberucci, A., Chen, J., Liu, B., Vangheluwe, P., Gorelli, B., Lorenzini, S., Spiga, O., Trezza, A., Sgaragli, G., Saponara, S. (2018). Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak. BIOCHEMICAL PHARMACOLOGY, 155, 434-443. doi: 10.1016/j.bcp.2018.07.026

Smaardijk, S., Chen, J., Kerselaers, S., Voets, T., Eggermont, J., Vangheluwe, P. (2018). Store-independent coupling between the Secretory Pathway Ca2+ transport ATPase SPCA1 and Orai1 in Golgi stress and Hailey-Hailey disease. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1865 (6), 855-862. doi: 10.1016/j.bbamcr.2018.03.007 Open Access

Sorensen, D.M., Holemans, T., van Veen, S., Martin, S., Arslan, T., Haagendahl, I.W., Holen, H.W., Hamouda, N.N., Eggermont, J., Palmgren, M., Vangheluwe, P. with Sorensen, D.M. (joint first author), Holemans, T. (joint first author) (2018). Parkinson disease related ATP13A2 evolved early in animal evolution. PLOS ONE, 13 (3), Art.No. ARTN e0193228. doi: 10.1371/journal.pone.0193228 Open Access

Mikkelsen, S.A., Vangheluwe, P., Andersen, J.P. (2018). A Darier disease mutation relieves kinetic constraints imposed by the tail of sarco(endo)plasmic reticulum Ca-ATPase 2b. Journal of Biological Chemistry, 293 (11), Art.No. jbc.RA117.000941, 3880-3889. Open Access

Martin, S., Dudek-Peric, A.M., Garg, A., Roose, H., Demirsoy, S., Van Eygen, S., Mertens, F., Vangheluwe, P., Vankelecom, H., Agostinis, P. (2017). An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAF(V600E) inhibitor-resistant metastatic melanoma cells. Autophagy, 13 (9), Art.No. 10.1080/15548627.2017.1332550, 1512-1527. Open Access

Demirsoy, S., Martin, S., Motamedi, S., van Veen, S., Holemans, T., Van den Haute, C., Jordanova, A., Baekelandt, V., Vangheluwe, P., Agostinis, P. (2017). ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function. Human Molecular Genetics, 26 (9), Art.No. 10.1093/hmg/ddx070, 1656-1669.

Chen, J., De Raeymaecker, J., Hovgaard, J.B., Smaardijk, S., Vandecaetsbeek, I., Wuytack, F., Møller, J.V., Eggermont, J., De Maeyer, M., Christensen, S.B., Vangheluwe, P. (2017). Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+ Transport ATPase (SPCA1a). Journal of Biological Chemistry, 292 (17), Art.No. jbc.M117.778431, 6938-6951. Open Access

Smaardijk, S., Chen, J., Wuytack, F., Vangheluwe, P. (2017). SPCA2 couples Ca influx via Orai1 to Cauptake into the Golgi/secretory pathway. Tissue & Cell, 49 (2), Art.No. S0040-8166(16)30097-0, 141-149. doi: 10.1016/j.tice.2016.09.004 Open Access

Bittremieux, M., Gerasimenko, J.V., Schuermans, M., Luyten, T., Stapleton, E., Alzayady, K.J., De Smedt, H., Yule, D.I., Mikoshiba, K., Vangheluwe, P., Gerasimenko, O.V., Parys, J., Bultynck, G. (2017). DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store. Cell Calcium, 62, 60-70. doi: 10.1016/j.ceca.2017.01.015

Estrada-Cuzcano, A., Martin, S., Chamova, T., Synofzik, M., Timmann, D., Holemans, T., Andreeva, A., Reichbauer, J., De Rycke, R., Chang, D-I., van Veen, S., Samuel, J., Schöls, L., Pöppel, T., Sorensen, D.M., Asselbergh, B., Klein, C., Zuchner, S., Jordanova, A., Vangheluwe, P., Tournev, I., Schüle, R. (2017). Loss-of-function mutations in the ATP13A2/PARK9 gene cause complicated hereditary spastic paraplegia (SPG78). Brain, 140 (2), 287-305.

Tharkeshwar, A.K., Trekker, J., Vermeire, W., Pauwels, J., Sannerud, R., Priestman, D.A., Te Vruchte, D., Vints, K., Baatsen, P., Decuypere, J-P., Lu, H.Q., Martin, S., Vangheluwe, P., Swinnen, J., Lagae, L., Impens, F., Platt, F.M., Gevaert, K., Annaert, W. (2017). A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency. Scientific Reports, 7, Art.No. 10.1038/srep41408.

Martin, S., van Veen, S., Holemans, T., Demirsoy, S., van den Haute, C., Baekelandt, V., Agostinis, P., Eggermont, J., Vangheluwe, P. with Martin, S. (joint first author), van Veen, S. (joint first author) (2016). Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2. PARKINSONS DISEASE, Art.No. ARTN 9531917. doi: 10.1155/2016/9531917 Open Access

Vandecaetsbeek, I., Vangheluwe, P. (2016). Time-Dependent Protein Thermostability Assay. Methods in Molecular Biology, 1377, Art.No. 10.1007/978-1-4939-3179-8_9, 79-85.

Kecskes, M., Jacobs, G., Kerselaers, S., Syam, N., Menigoz, A., Vangheluwe, P., Freichel, M., Flockerzi, V., Voets, T., Vennekens, R. (2015). The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy. Basic Research in Cardiology, 110 (4), Art.No. 10.1007/s00395-015-0501-x.

Holemans, T., Sørensen, D.M., van Veen, S., Martin, S., Hermans, D., Kemmer, G.C., Van Den Haute, C., Baekelandt, V., Günther Pomorski, T., Agostinis, P., Wuytack, F., Palmgren, M., Eggermont, J., Vangheluwe, P. (2015). A lipid switch unlocks Parkinson's disease-associated ATP13A2. Proceedings of the National Academy of Sciences of the United States of America, 112 (29), Art.No. 201508220, 9040-9045.

Sørensen, D.M., Holen, H.W., Holemans, T., Vangheluwe, P., Palmgren, M.G. (2015). Towards defining the substrate of orphan P5A-ATPases. Biochimica et Biophysica Acta, 1850 (3), Art.No. S0304-4165(14)00165-2, 524-535. Open Access

Martin, S., Holemans, T., Vangheluwe, P. (2015). Unlocking ATP13A2/PARK9 activity. Cell Cycle, 14 (21), 3341-3342. Open Access

Vandecaetsbeek, I., Holemans, T., Wuytack, F., Vangheluwe, P. (2014). High-throughput measurement of the Ca2+-dependent ATPase activity in COS microsomes. Cold Spring Harbor Protocols, 2014 (8), Art.No. 10.1101/pdb.prot076885, 865-75.

Holemans, T., Vandecaetsbeek, I., Wuytack, F., Vangheluwe, P. (2014). Measuring Ca2+ pump activity in overexpression systems and cardiac muscle preparations. Cold Spring Harbor Protocols, 2014 (8), Art.No. 10.1101/pdb.top066134, 876-86. doi: 10.1101/pdb.top066134

Holemans, T., Vandecaetsbeek, I., Wuytack, F., Vangheluwe, P. (2014). Measuring Ca2+-dependent Ca2+-uptake activity in the mouse heart. Cold Spring Harbor Protocols, 2014 (8), Art.No. 10.1101/pdb.prot076893, 876-86.

van Veen, S., Sørensen, D.M., Holemans, T., Holen, H.W., Palmgren, M.G., Vangheluwe, P. (2014). Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders. Frontiers in Molecular Neuroscience, 7, Art.No. 10.3389/fnmol.2014.00048. Open Access

Wakai, T., Zhang, N., Vangheluwe, P., Fissore, R.A. (2013). Regulation of endoplasmic reticulum Ca2+ oscillations in mammalian eggs. Journal of Cell Science, 126, 5714-5724. Open Access

Gorski, P.A., Glaves, J.P., Vangheluwe, P., Young, H.S. (2013). Sarco(endo)plasmic Reticulum Calcium ATPase (SERCA) Inhibition by Sarcolipin Is Encoded in Its Luminal Tail. Journal of Biological Chemistry, 288 (12), 8456-8467. Open Access

Clausen, J.D., Vandecaetsbeek, I., Wuytack, F., Vangheluwe, P., Andersen, J.P. (2012). Distinct Roles of the C-terminal 11th Transmembrane Helix and Luminal Extension in the Partial Reactions Determining the High Ca2+ Affinity of Sarco(endo)plasmic Reticulum Ca2+-ATPase Isoform 2b (SERCA2b). Journal of Biological Chemistry, 287 (47), 39460-39469.

Sørensen, D.M., Møller, A.B., Jakobsen, M.K., Jensen, M.K., Vangheluwe, P., Buch-Pedersen, M.J., Palmgren, M.G. (2012). Ca2+ Induces Spontaneous Dephosphorylation of a Novel P5A-type ATPase. Journal of Biological Chemistry, 287 (34), 28336-28348.

Sepúlveda, M.R., Dresselaers, T., Vangheluwe, P., Everaerts, W., Himmelreich, U., Mata, A.M., Wuytack, F. (2012). Evaluation of manganese uptake and toxicity in mouse brain during continuous MnCl2 administration using osmotic pumps. Contrast Media & Molecular Imaging, 7 (4), 426-434.

Gorski, P.A., Trieber, C.A., Larivière, E., Schuermans, M., Wuytack, F., Young, H.S., Vangheluwe, P. (2012). Transmembrane helix 11 is a genuine regulator of the endoplasmic reticulum Ca2+ pump and acts as a functional parallel of β-subunit on α-Na+,K+-ATPase. Journal of Biological Chemistry, 287 (24), 19876-19885.

Louch, W.E., Vangheluwe, P., Bito, V., Raeymaekers, L., Wuytack, F., Sipido, K. (2012). Phospholamban ablation in hearts expressing the high affinity SERCA2b isoform normalizes global Ca²⁺ homeostasis but not Ca²⁺-dependent hypertrophic signaling. American Journal of Physiology. Heart and Circulatory Physiology, 302 (12).

Vandecaetsbeek, I., Vangheluwe, P., Raeymaekers, L., Wuytack, F., Vanoevelen, J. (2011). The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus. Cold Spring Harbor perspectives in biology, 3 (5).

Vangheluwe, P., Wuytack, F. (2011). Improving cardiac Ca2+ transport into the sarcoplasmic reticulum in heart failure: lessons from the ubiquitous SERCA2b Ca2+ pump. Biochemical Society Transactions, 39 (3), 781-787.

Vandecaetsbeek, I., Vangheluwe, P., Raeymaekers, L., Wuytack, F., Vanoevelen, J. (2011). The Ca2+ Pumps of the Endoplasmic Reticulum and Golgi Apparatus. Cold Spring Harbor Perspectives in Biology, 3 (5), Art.No. a004184. doi: 10.1101/cshperspect.a004184

Vandecaetsbeek, I., Christensen, S.B., Liu, H., Van Veldhoven, P.P., Waelkens, E., Eggermont, J., Raeymaekers, L., Møller, J.V., Nissen, P., Wuytack, F., Vangheluwe, P. (2011). Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases. Biochimica et Biophysica Acta. Molecular Cell Research, 1813 (5), 1118-1127.

Raeymaekers, L., Vandecaetsbeek, I., Wuytack, F., Vangheluwe, P. (2011). Modeling of Ca2+ dynamics of mouse cardiac cells points to a critical role of SERCA's affinity for Ca2+. Biophysical Journal, 100, 1216-1225.

Baron, S., Vangheluwe, P., Sepúlveda, M.R., Wuytack, F., Raeymaekers, L., Vanoevelen, J. (2010). The secretory pathway Ca(2+)-ATPase 1 is associated with cholesterol-rich microdomains of human colon adenocarcinoma cells. Biochimica et Biophysica Acta. Biomembranes, 1798 (8), 1512-1521.

Sipido, K., Vangheluwe, P. (2010). Targeting sarcoplasmic reticulum Ca2+ uptake to improve heart failure: hit or miss. Circulation Research, 106 (2), 230-233.

Van den Bergh, A., Vangheluwe, P., Vanderper, A., Carmeliet, P., Wuytack, F., Janssens, S., Flameng, W., Holvoet, P., Herijgers, P. (2009). Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve. European Journal of Heart Failure, 11 (12), 1118-1125.

Vandecaetsbeek, I., Raeymaekers, L., Wuytack, F., Vangheluwe, P. (2009). Factors controlling the activity of the SERCA2a pump in the normal and failing heart. BioFactors, 35 (6), 484-499.

Vandecaetsbeek, I., Trekels, M., De Maeyer, M., Ceulemans, H., Lescrinier, E., Raeymaekers, L., Wuytack, F., Vangheluwe, P. (2009). Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump. Proceedings of the National Academy of Sciences of the United States of America, 106 (44), 18533-18538. Open Access

Vangheluwe, P., Sepulveda, M.R., Missiaen, L., Raeymaekers, L., Wuytack, F., Vanoevelen, J. (2009). Intracellular Ca(2+)- and Mn(2+)-Transport ATPases. Chemical Reviews, 109 (10), 4733-4759.

Ottenheijm, C.A C., Fong, C., Vangheluwe, P., Wuytack, F., Babu, G.J., Periasamy, M., Witt, C.C., Labeit, S., Granzier, H. (2008). Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle. FASEB Journal, 22 (8), 2912-2919.

Loyer, X., Gomez, A.M., Milliez, P., Fernandez-Velasco, M., Vangheluwe, P., Vinet, L., Charue, D., Vaudin, E., Zhang, W., Sainte-Marie, Y., Robidel, E., Marty, I., Mayer, B., Jaisser, F., Mercadier, J-J., Richard, S., Shah, A.M., Benitah, J-P., Samuel, J-L., Heymes, C. (2008). Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling. Circulation, 117 (25), 3187-3198.

Van den Bergh, A., Vanderper, A., Vangheluwe, P., Desjardins, F., Nevelsteen, I., Verreth, W., Wuytack, F., Holvoet, P., Flameng, W., Balligand, J-L., Herijgers, P. (2008). Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffness. Cardiovascular Research, 77 (2), 371-379. Open Access

Vangheluwe, P., Schuermans, M., Raeymaekers, L., Wuytack, F. (2007). Tight interplay between the Ca2+ affinity of the cardiac SERCA2 Ca2+ pump and the SERCA2 expression level. Cell Calcium, 42 (3), 281-289.

Zádor, E., Vangheluwe, P., Wuytack, F. (2007). The expression of the neonatal sarcoplasmic reticulum Ca(2+) pump (SERCA1b) hints to a role in muscle growth and development. Cell Calcium, 41 (4), 379-388.

Vangheluwe, P., Sipido, K., Raeymaekers, L., Wuytack, F. (2006). New perspectives on the role of SERCA2's Ca(2+) affinity in cardiac function. Biochimica et Biophysica Acta. Molecular Cell Research, 1763 (11), 1216-1228.

Vangheluwe, P., Tjwa, M., Van Den Bergh, A., Louch, W.E., Beullens, M., Dode, L., Carmeliet, P., Kranias, E., Herijgers, P., Sipido, K., Raeymaekers, L., Wuytack, F. (2006). A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span. Journal of Molecular and Cellular Cardiology, 41 (2), 308-317.

Antoons, G., Vangheluwe, P., Volders, P.G A., Bito, V., Holemans, P., Ceci, M., Wuytack, F., Caroni, P., Mubagwa, K., Sipido, K. (2006). Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure. Journal of Molecular and Cellular Cardiology, 40 (3), 350-60.

Vangheluwe, P., Raeymaekers, L., Dode, L., Wuytack, F. (2005). Modulating sarco(endo)plasmic reticulum Ca2+ ATPase 2 (SERCA2) activity: cell biological implications. Cell Calcium, 38 (3), 291-302. doi: 10.1016/j.ceca.2005.06.033

Vangheluwe, P., Schuermans, M., Zádor, E., Waelkens, E., Raeymaekers, L., Wuytack, F. (2005). Sarcolipin and phospholamban mRNA and protein expression in cardiac and skeletal muscle of different species. Biochemical Journal, 389, 151-159.

Vangheluwe, P., Louch, W.E., Ver Heyen, M., Sipido, K., Raeymaekers, L., Wuytack, F. (2003). Ca2+ transport ATPase isoforms SERCA2a and SERCA2b are targeted to the same sites in the murine heart. Cell Calcium, 34 (6), 457-464.

Antoons, G., Ver Heyen, M., Raeymaekers, L., Vangheluwe, P., Wuytack, F., Sipido, K. (2003). Ca2+ uptake by the sarcoplasmic reticulum in ventricular myocytes of the SERCA2b/b mouse is impaired at higher Ca2+ loads only. Circulation Research, 92 (8), 881-7.

Ver Heyen, M., Heymans, S., Antoons, G., Reed, T., Periasamy, M., Awede, B., Lebacq, J., Vangheluwe, P., Dewerchin, M., Collen, D., Sipido, K., Carmeliet, P., Wuytack, F. (2001). Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart. Circulation Research, 89 (9), 838-46.

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